Peyton Manning‘s got one HUGE obstacle to overcome if he wants to slay at the “Comedy Central Roast” of Rob Lowe — but Jeff Ross says the QB is already showing serious promise. 

“Athletes are funny, but they don’t always take a joke well,” Ross told us at The Comedy Store in L.A. 

“They’re usually very sensitive.”

FYI, several athletes have been featured on ‘Roasts’ in the past — including Warren Sapp, Mike Tyson and Shaq. 

The good news for Manning … Ross says Peyton has already proved he has thick skin — and expects nothing less than hilarity when #18 takes the stage. 

Meantime, he has one piece of advice for Manning … “Wear a helmet.”

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